Book, Papers & Presentations


Reflecting decades of research, the following book is now available:

Allergy and Cross-Reactivity, Sue C. Killian, MS, with John McMichael, PhD. Indianapolis: Xlibris, 2017.

Peer-Reviewed Publications

Following are representative papers and presentations focusing on Resonant Molecular Signaling formulations.

“Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmdmdx Mice,” Volkan Gurel, Jeremy Lins, Kristyn Lambert, Joan Lazauski, James Spaulding, John McMichael. Dose-Response, 13, 1-8, October-December 2015, doi:10.1177/1559325815616351.

"Allergy Induced Back Pain: A Report of Two Cases,” Sue Killian and John McMichael. Journal of Allergy Disorders and Therapy, Vol. 2, Issue 1, 1-4, 2015.

"Combination histamine and serotonin treatment after simulated childbirth injury improves stress urinary incontinence," Qi-Xiang Song, Brian M. Balog, Dan Li Lin, Hai-Hong Jiang, Volkan Gurel, James Spaulding, Julia Tobacyk, John McMichael, and Margot S. Damaser. Neurourology and Urodynamics, article first published online: DOI:10.1002/nau.22793, 17 June 2015.

"Streptolysin-O/Antibiotics Adjunct Therapy Modulates Site-specific Expression of Extracellular Matrix and Inflammatory Genes in Lungs of Rhodococcus equi Infected Foals," Volkan Gurel, Kristyn Lambert, Allen E. Page, Alan T. Loynachan, Katherine Huges, John F. Timoney, Michael Fettinger, David W. Horohov, John McMichael. Veterinary Research Communications, DOI 10.1007/s11259-013-9557-y, March 2013.

"The use of streptolysin O (SLO) as an adjunct therapy for Rhodococcus equi pneumonia in foals," David W. Horohov, Alan T. Loynachan, Allen E. Page, Katherine Hughes, John F. Timoney, Michael Fettinger, Thomas Hatch, James G. Spaulding, John McMichael. Veterinary Microbiology, 154, 156–162, 2011.

"Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain," John E. McGeary, Volkan Gurel, Valerie S. Knopik, James Spaulding, John McMichael. Neuropeptides, Vol. 45, Issue 5, 317-322, October 2011.

"Effects of Streptolysin O on Extracellular Matrix Gene Expression in Normal Human Epidermal Keratinocytes," Stephen W. Mamber, Volkan Gurel, Ryan G. Rhodes, John McMichael. Dose-Response, 9, 554-578, 2011.

"Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of
the EGF receptor ErbB1," Emily H. Hall, Volkan Gurel, Albert E. Dahlberg, John McMichael, David L. Brautigan. Cellular Signaling, 23, 1972-1977, 2011.

"Nerve growth factor (NGF) has novel antidepressant-like properties in rats,"
David H. Overstreet, Kellie Frederick, Darin Knapp, George Breese, John McMichael. Pharmacology, Biochemistry and Behavior, 94, 553–560, 2010.

“Evaluation of a novel immunomodulator composed of human chorionic gonadotropin and bacillus Calmette-Guerin for treatment of canine mast cell tumors in clinically affected dogs,” Carolyn J. Henry, Sue Downing, Robert C. Rosenthal, Mary Kay Klein, Kari Meleo, J. Armando Villamil, Linda S. Fineman, Dudley L. McCaw, Mary Lynn Higginbotham, John McMichael. American Journal of Veterinary Research, Vol. 68, No. 11, 1246-1251, November 2007.

“Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro." Tomic-Canic, M, Mamber SW, Stojadinovic O, Lee B, Radoja N, McMichael. Wound Repair and Regeneration, Vol. 15(1):71-79, 2007.

“Microdose DNA for the Treatment of Acute and Chronic Respiratory Diseases and Otitis Media,” Stephen Mamber and John McMichael. The Journal of the American Nutraceutical Association, Vol. 9, No. 1, 13-22, 2006.

“The use of streptolysin O for the treatment of scars, adhesions and fibrosis: Initial investigations using murine models of scleroderma.” Mamber SW, Long V, Rhodes RG, Pond-Tor S, Wheeler LR, Fredericks K, Vanscoy B, Sauniere J. F, Steinschneider R, Laurent J. C, McMichael J. Nonlinearity in Biology, Toxicology and Medicine, Apr-Jun;2(2):67-87, 2004.

“A Trial Study: The Effect of Low Dose Human Chorionic Gonadotropin on the Symptoms of Benign Prostatic Hyperplasia,” Michael F. Godschalk, Kenneth A. Unice, Donald Bergner, P. Gary Katz, Thomas Mulligan, John McMichael. The Journal of Urology, Vol. 170, 1264-1269, 2003.

“Enhancement of radiosensitivity of the MCF-7 breast cancer cell line with human chorionic gonadotropin,” Sunthorn Pond-Tor, Ryan G. Rhodes, Paul E. Dahlberg, John T. Leith, John McMichael, Albert E. Dahlberg. Breast Cancer Research and Treatment, Vol. 72: 45-51, 2002.

“Open-Label Pilot Study of the Safety and Efficacy of LDI-200 in the Treatment of Cancer-Associated Pain,” Lloyd Saberski, Hanne Peterson, John McMichael. The Pain Clinic, June 2001.

“Modulating Activity of Human Chorionic Gonadotropin on Growth and Tumorigenesis of Prostate Cancer Cells,” Jen Wei Chiao, Karen Turo, Yang Ming Yang, Eric Feldman, Frank Traganos, Delores Halicka, Ram Kancherla, S Robert Fatora, Tauseef Ahmed, John McMichael. Molecular Urology, Vol. 2, No. 2, 57-63, 1998.

In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia,” EJ Feldman, K Seiter, JW Chiao, HD Halicka, F Tragonos, SR Fatora, J McMichael, P Baskind, H Goff, M Beer, T Ahmed, Z Darzynkiewicz. Leukemia, 12: 1749-1755, 1998.


Society for Scientific Exploration Conference, May 2015, Washington DC:

  • "A Novel Medical Treatment for Traumatic Brain Injury," John McMichael.

Preconditioning in Biology and Medicine Mechanisms and Translational Research Conference, April 2015, University of Massachusetts, Amherst:

  • “Serotonin and Histamine Therapy Increases Tetanic Forces of Myoblasts, Reduces Muscle Injury, and Improves Grip Strength Performance of Dmdmdx Mice,” Gurel V, Lins J, Lamber K, Lazauski J, Spaulding J, McMichael J.

Society for Scientific Exploration Conference, June 2014, San Francisco:

  • "Effects of Subtle Energy Patterns on Gene Regulation of Human Dermal Fibroblasts," Jeremy Lins.

Society for Scientific Exploration Conference, June 2011, Boulder, CO:

  • "Resonant Molecular Signaling: From Theory to Practice," John McMichael.

Dose-Response 2010: Implications for Toxicology, Medicine, and Risk Assessment, April 2010, University of Massachusetts, Amherst:

  • Paper: "Detoxified Streptolysin O: Effects on Extracellular Matrix and Immune Response Gene Expression in Pathway-focused DNA Microarrays," Stephen Mamber.
  • Poster: "Effects of Low Dose Thimerosal on Immune Response Gene Expression in Human Dermal Fibroblast Cells," Stephen Mamber, Volkan Gurel, John McMichael.

The Fifth International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 2006, University of Massachusetts, Amherst:

  • “Streptolysin O Enhances Keratinocyte Migration and Proliferation, and
    Promotes Skin Organ Culture Wound Healing,” Stephen Mamber.

The Third International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 2004, University of Massachusetts, Amherst:

  • “The Use of Low Dose Thimerosal for the Treatment of Type A Influenza,” John McMichael.

World Federation of Societies of Biological Psychiatry Conference, February 2004, Sydney, Australia:

  • “Antidepressant-like effects of NGF in a genetic animal model of depression,” Overstreet DH, Fredericks K, Knapp DJ, McMichael J.
Copyright Beech Tree Labs, Inc.