Papers and Presentations

Following are representative papers and presentations focusing on Resonant Molecular Signaling formulations.

Peer-Reviewed Publications

"Nerve growth factor (NGF) has novel antidepressant-like properties in rats,"
David H. Overstreet, Kellie Frederick, Darin Knapp, George Breese, John McMichael. Pharmacology, Biochemistry and Behavior, 94, 553–560, 2010.

“Evaluation of a novel immunomodulator composed of human chorionic gonadotropin and bacillus Calmette-Guerin for treatment of canine mast cell tumors in clinically affected dogs,” Carolyn J. Henry, Sue Downing, Robert C. Rosenthal, Mary Kay Klein, Kari Meleo, J. Armando Villamil, Linda S. Fineman, Dudley L. McCaw, Mary Lynn Higginbotham, and John McMichael. American Journal of Veterinary Research, Vol. 68, No. 11, 1246-1251, November 2007.

“Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro." Tomic-Canic, M, Mamber SW, Stojadinovic O, Lee B, Radoja N, and McMichael J. Wound Repair and Regeneration, Vol. 15(1):71-79, 2007.

“Microdose DNA for the Treatment of Acute and Chronic Respiratory Diseases and Otitis Media,” Stephen Mamber and John McMichael. The Journal of the American Nutraceutical Association, Vol. 9, No. 1, 13-22, 2006.

“The use of streptolysin O for the treatment of scars, adhesions and fibrosis: Initial investigations using murine models of scleroderma.”  Mamber SW, Long V, Rhodes RG, Pond-Tor S, Wheeler LR, Fredericks K, Vanscoy B, Sauniere J.-F, Steinschneider R, Laurent J.-C, and McMichael J. Nonlinearity in Biology, Toxicology and Medicine, Apr-Jun;2(2):67-87, 2004.

“A Trial Study: The Effect of Low Dose Human Chorionic Gonadotropin on the Symptoms of Benign Prostatic Hyperplasia,” Michael F. Godschalk, Kenneth A. Unice, Donald Bergner, P. Gary Katz, Thomas Mulligan, and John McMichael. The Journal of Urology, Vol. 170, 1264-1269, 2003.

“Enhancement of radiosensitivity of the MCF-7 breast cancer cell line with human chorionic gonadotropin,” Sunthorn Pond-Tor, Ryan G. Rhodes, Paul E. Dahlberg, John T. Leith, John McMichael, and Albert E. Dahlberg. Breast Cancer Research and Treatment, Vol. 72: 45-51, 2002.

“Open-Label Pilot Study of the Safety and Efficacy of LDI-200 in the Treatment of Cancer-Associated Pain,” Lloyd Saberski, Hanne Peterson, and John McMichael. The Pain Clinic, June 2001.

“Modulating Activity of Human Chorionic Gonadotropin on Growth and Tumorigenesis of Prostate Cancer Cells,” Jen Wei Chiao, Karen Turo, Yang Ming Yang, Eric Feldman, Frank Traganos, Delores Halicka, Ram Kancherla, S Robert Fatora, Tauseef Ahmed, and John McMichael. Molecular Urology, Vol. 2, No. 2, 57-63, 1998.

“In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia,” EJ Feldman, K Seiter, JW Chiao, HD Halicka, F Tragonos, SR Fatora, J McMichael, P Baskind, H Goff, M Beer, T Ahmed, and Z Darzynkiewicz. Leukemia, 12: 1749-1755, 1998.

Presentations

Presentations at Dose-Response 2010: Implications for Toxicology, Medicine, and Risk Assessment, April 27-28, 2010, at the University of Massachusetts, Amherst, Mass.:

• Paper: "Detoxified Streptolysin O: Effects on Extracellular Matrix and Immune Response Gene Expression in Pathway-focused DNA Microarrays," Mamber S.
• Poster: "Effects of Low Dose Thimerosal on Immune Response Gene Expression in Human Dermal Fibroblast Cells," Mamber S, Gurel V, McMichael J.

Paper presented at the Fifth International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 6-8 2006, at the University of Massachusetts, Amherst, Mass.:

• “Streptolysin O Enhances Keratinocyte Migration and Proliferation, and
  Promotes Skin Organ Culture Wound Healing,” Mamber S.

Paper presented at the Third International Conference on Non-Linear Dose-Response Relationships in Biology, Toxicology, and Medicine, June 8-10, 2004, at the University of Massachusetts, Amherst, Mass.:

• “The Use of Low Dose Thimerosal for the Treatment of Type A Influenza,” McMichael JM.

Paper presented at World Federation of Societies of Biological Psychiatry, February 9-13, 2004, Sydney, Australia:

• “Antidepressant-like effects of NGF in a genetic animal model of depression,” Overstreet DH, Fredericks K, Knapp DJ, McMichael JM. Presentation #5215.